Psoriasis is linked to a gene mapped to the distal end of the 17th chromosome (see article below from Dermatology Times, "Spice Shows Promise as Powerful Skin Disease Treatment"). This gene encodes an abnormal cyclic AMP (Type II) which fails to switch-off the activity of phosphorylase kinase. After injury (trauma, allergic reactions, infections), phosphorylase kinase activity is induced.
Elevated phosphorylase kinase activity not only breaks down glycogen into ATP needed for multiple reactions, but activates IkBa kinase, a key enzyme responsible for activating NFkB, a transcription activator. Activation of NFkB then goes on to turn on over 200 genes responsible for cell proliferation, cell cyling, inhibition of apoptosis etc, resulting in the formation of PCNA+ (proliferating cell nuclear antigen), detected by the immunocytochemical marker, Ki-67+ . The Ki-67+ cells are capable of producing new cells and their increased numbers in the basal keratinocyte layers of the psoriatic epidermis is responsible for the hyperproliferation characteristic of the psoriatic disease.